Posted by: arisfil | February 17, 2008

Alzheimer’s and TNF-alpha antagonist

Alois Alzheimer Alois Alzheimer

Literature indicates that elevated levels of TNF-alpha may play an orchestrating role in the pathogenesis of Alzheimer’s. A novel drug (etanercept) that belongs to the category of TNF-alpha antagonists, a new delivery method (paraspinal) and its efficacy are tested in an aricle by Tobinik and Gross in Journal of Neuroinflammation published in January 2008. The authors state that the utilization of etanercept gave rise to a rapid congitive improvement when tested to a patient with Altzheimer’s disease. Various cognitive tests before and after etanercept administration were used and showed substantial differences.

Journal of Neuroinflammation 2008, 5:2 

This report of course is a preliminary report, in a sole case. Further wide-scale and properly organized clinical trials should be designed in order to prove and interpret the efficacy of the drug.

This article is under the Open Access initiative and can be accessed though LINK or PDF.

© 2008 Tobinick and Gross; licensee BioMed Central Ltd.  


  1. Does anyone know of where else this treatment is offered? What parts of the US and the world?

  2. Well, this drug is FDA approved under the label Enbrel® for rheumatoid arthritis and it is not officially indicated for Altzheimer’s. The results demonstrated are preliminary and case-based. Also these data are experimentally and should not be taken for granted since further research has to be done.

    To my knowledge I don’t know if a center applies this therapy. Maybe you could be informed by the authors of the paper.


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