Posted by: arisfil | March 24, 2008

NSAIDs and Low Back Pain

Sciatic nerve 

The evidence-based medical journal Cochrane Database of Systematic Reviews, published in 28th of January a meta-analysis article by Dr Roelofs et al. The aim of the study was to access the ability of non-steroidal anti-inflammatory drugs (NSAIDs) and COX inhibitors concerning the treatment of non-specific low back pain with or without sciatica. They included 65 trials with 11,237 patients enrolled.

The authors found that NSAIDs are NOT more effective than other drugs (e.g. paracetamol/acetaminophen, narcotic, muscle relaxants). The COX treated group showed fewer side effects in the form of peptic ulcers but we should recall that they are associated with increased cardiovascular risk.

The authors noted that few clinical trials were of high quality (only 42%) show more data are needed for long term results.

 Please read the abstract by clicking the link:

Roelofs PDDM, Deyo RA, Koes BW, Scholten RJPM, van Tulder MW. Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD000396

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